Targeted Cargo Delivery in Senescent Cells Using Capped Mesoporous Silica Nanoparticles


Intracellular controlled release of molecules within senescent cells was achieved using mesoporous silica nanoparticles(MSNs) capped with a galacto-oligosaccharide (GOS) to contain the cargo molecules (magenta spheres; see scheme). The GOS is a substrate of the senescent biomarker, senescence-associated β-galactosidase (SA-β-gal), and releases the cargo upon entry into SA-β-gal expressing cells.

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The main focus of ageing research is to prevent/combat age-related disease and disability, allowing everyone to live healthier lives for longer.