Targeted Cargo Delivery in Senescent Cells Using Capped Mesoporous Silica Nanoparticles

Abstract

Intracellular controlled release of molecules within senescent cells was achieved using mesoporous silica nanoparticles(MSNs) capped with a galacto-oligosaccharide (GOS) to contain the cargo molecules (magenta spheres; see scheme). The GOS is a substrate of the senescent biomarker, senescence-associated β-galactosidase (SA-β-gal), and releases the cargo upon entry into SA-β-gal expressing cells.

Link: http://1.usa.gov/TFDGVS